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Gastrointestinal
Antiemetics
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GRANOVELL
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Indications
Granovell is indicated for the prevention and treatment (control) of a. Acute and delayed nausea and vomiting associated with chemotherapy and radiotherapy b. Post-operative nausea and vomiting
Pharmacology
Each mL injection contains 1,12 mg Granisetron Hydrochloride equivalent to 1 mg Granisetron
Package Quantities
Box, 5 ampoules @ 1 ml. Box, 5 ampoules @ 3 ml.
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GRANOVELL
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Indications
Granovell is indicated for the prevention and treatment (control) of : a. Acute and delayed nausea and vomiting associated with chemotherapy and radiotherapy. b. Post-operative nausea and vomiting. MECHANISM OF ACTION Serotonin receptors of the 5-HT3 type are located peripherally in vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. During chemotherapy-induced vomiting, mucosal entereochromaffin cells release serotonin, which stimulates 5-HT3 receptors. This invokes vagal afferent discharge, inducing vomiting. Granovell is a potent anti-emetic and highly selective antagonist of 5- hydroxytryptamine (5-HT3) receptors. Radioligand binding studies have demonstrated that Granovell has negligible affinity affinity for other receptor types including 5- HT and dopamine D2 binding sites.
Pharmacology
Each mL injection contains 1.12 mg Granisetron Hydrochloride equivalent to 1 mg Granisetron.
Package Quantities
Box, 5 ampoules @ 1 mL. Box, 5 ampoules @ 3 mL.
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Ondavell 4 ODT
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Indications
Management of nausea & vomiting induced by cytotoxic chemo- & radiotherapy.
Pharmacology
Ondansetron....................... 4 mg
Package Quantities
Box, 1 Blister @10 Tablet ODT
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Ondavell 8 ODT
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Indications
Ondavell ODT is indicated for nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy management. Ondavell ODT also indicated for prevention of post-operative nausea and vomiting
Pharmacology
Ondansetron.......................................8mg
Package Quantities
Box with 1 blister @ 10 Orally Disintegrating Tabl
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Ondavell Injeksi
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Indications
Manage nausea and vomiting induced by cytotoxic
chemotherapy and radiotherapy
Pharmacology
Each ONDAVELL inj 8 mg contains: Ondansetron ……………8 mg
Package Quantities
Box, 5 ampoules @ 2 mL
Box, 5
ampoules @ 4 mL
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RAMOZEA
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Indications
- Symptoms of gastrointestinal (nausea and vomiting) related carcinostatics ( as cisplatin) - Post operative nausea and vomiting
Pharmacology
Ramosetron HCl .......................................... 0,3 mg/2 mL
Package Quantities
Box, ampul @2 mL
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Setrovel
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Indications
Setrovel is used as prevention of cancer
chemotheraphy-induced nausea and vomiting. For PONV (Post Operative Nausea and Vomiting)
Pharmacology
Each ml SETROVEL injection contains: Tropisentron HCl....….1.13 mg
Package Quantities
Box of 10
ampoules @ 5 ml
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